Topics                                                                 Week
	
Introduction  	                                                          I
 
Basic Instrumentation - Overview, Fundamentals  			 II
     Sample Introduction 
          Batch Inlet
          Direct Insertion Probe
          Chromatographic Connections
     Ion Source
     Mass Analyzers
          Basic Components
          Resolving Power
     Ion Detectors
          Photoplate
          Faraday Cage
          Electron Multiplier
          Others
     Vacuum System
     Data System  

Ionization Techniques					         	III

     Electron (Impact) Ionization (EI)
          High Electron Beam Voltage EI
          Low Electron Beam Voltage EI
     Chemical Ionization (CI)
          Methane CI  
	  Isobutane CI
	  Ammonia CI
	  Deuterated Ammonia CI
	  Negative Ion Production
     Photo-ionization						         IV
     Laser Ionization/Laser Desorption/Matrix-Assisted Laser 
        Desorption Ionization (MALDI)
     Field Ionization/Field Desorption
     Fast Atom Bombardment/Liquid Secondary Ion MS (LSIMS)
     Atmospheric Pressure Ionization
          Atmospheric Pressure Chemical Ionization (APCI)
          Electrospray
     Others (Discharge, Plasma Desorption, etc.)

Modern Mass Spectrometers					          V
     Magnetic (Sector)
          Single Focusing
          Double Focusing
     Quadrupole
     Time-of-Flight						         VI
     Fourier Transform Ion Cyclotron Resonance 
     Ion Trap

Types of Ions in Mass Spectra					        VII
     Molecular Ions
     Pseudo-molecular Ions
     Fragment Ions
     Metastable Ions
     Rearragement Ions
     Multiply-charge Ions
     Negative Ions

Theory of Electron Ionization					       VIII
     Energetics of Electron Impact Processes
          Ionization Potentials
          Appearance Potentials
          Heat of Formation of Ions
     Quasi-equilibrium Theory
          Rate Expression
          Energy Distribution
          Mass Spectral Calculations

High Resolution Mass Spectrometry				         IX
     General Issues
     Double Focusing Instruments
     Ion Cyclotron Resonance Instruments
     Mass Calibration

Combination with Other Analytical Instrumentation		          X
     Gas Chromatography/MS
          GC Techniques
          Interfaces
          Thermal Desorption/Pyrolysis (Coil, Ribbon, Curie Point)
     Liquid Chromatography/MS					         XI
          Moving Belt
          Particle Beam                
          Thermospray
          APCI/Electrospray
          Continuous Flow Fast Atom Bombardment
     Supercritical Fluid Chromatography/MS         
     Tandem MS (MS/MS)
     Thermogravimetric MS 

Mass Spectral Interpretations -                                         XII
     Isotopic Pattern Recognition
     Fragmentation and Rearrangement Processes
     Characteristic Ions/Neutral Losses
     Consolidated Information from Alternative Ionization Techniques
     Parent/Daughter Experiments

Analytical Applications					               XIII
     Selected Topics from:
          Hydrocarbon Analysis for Petroleum/Petrochemicals
          Quantitative Analysis
          Environmental (eg., TCDD)
          Biomarkers for Geoscience
          Pharmaceutical/Bioscience