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The Story of UsThe RARPEG lab group has been going strong for over 15 years. The lab is spread between two locations on the lush, expansive campus of Michigan State University. We belong to the Department of Pharmacology and Toxicology in the Life Sciences building and the
National Food Safety and Toxicology Center. The "mother" and "father" of our group are Drs. Patricia E. Ganey and Robert A. Roth. The rest of us who compose the group consist of post-docs, graduate students, research assistants, and undergraduates.
Most of the work done here focuses on mechanisms of tissue injury (especially the liver), and the relationship between inflammation and chemically-induced toxicity. Endotoxin (lipopolysaccharide) is a staple to many of the studies because of its production of a pronounced inflammatory response. Some students are working with dual treatments of endotoxin and drugs such as allyl alcohol, monocrotaline, and chlorpromazine to construct a rat model of inflammation and tissue injury. Other students are taking a molecular approach by looking at how the exposure of certain chemicals, such as polychlorinated biphenyls (PCBs), affects inflammatory cells. Another study is looking at the effects of thrombin on liver injury.
For a more in-depth look at the research occurring in the Roth/Ganey laboratories, click on their names above!
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