TOPICS ON JUNE 1998 STEP-1 EXAM:
1. SECOND MESSANGER SYSTEMS. (ALL HORMONES), EXACT MECH. AT MOLECULAR LEVEL.
STUDY IN DETAILS.
2. DRUGS RECEPTORS MECHANISM OF ACTION. EXACT MECH., RECEPTOR CHANGES, IONIC
CHANGES AND ULTIMATE OUTCOME.
3. ARACHIDONIC ACID METABOLISM. (ALL PG'S SYNTHESIS, THEIR BLOCKERS AT SPECIFIC
LEVELS. ASPIRIN VERY IMPORTANT.
4. MOST PHARMACOLOGY QUESTIONS IN CHART FORMAT. LIKE COMPARISON OF TWO DRUGS,
WITH THEIR INHIBITOR, ARROWS UP AND DOWN CHARTS AND DIAGRAMS. MOST QUESTIONS
FROM CVS (ANTI ARRYTHMIC very important) AND AUTONOMIC SYSTEMS.
5. MANY QUESTIONS ON DIABETES, HYPERTENSION, PRIMARY HEALTHCARE, MEDICAL ETHICS,
MICROBIAL GENETICS, CELL BIOLOGY AND NEUROANATOMY.
6. DIAGRAMS ON BOOK-B (1st DAY, 2nd BOOKLET) WERE MOSTLY GROSS PICTURES OF BRAIN
AND CT SCANS AND SPECIFIC LOCATION, SPECIFIC BRAIN LOBES (FUNCTIONS) OF THE
LESION WAS ASKED AFTER GIVING THE SYMPTOMS AND SIGNS (MOSTLY BLACK AND WHITE
DIGRAMS).
7. DIGRAMS ON BOOK-D (2nd DAY, 2nd BOOKLET) WERE MOSTLY HISTOPATHOLOGY,
DERMATOLOGY AND HEMATOLOGY (ALL COLORED DIGRAMS).
8. MOST OF THE QUESTIONS WERE ASKED ABOUT THE MECHANISM OR PATHOPHYSIOLOGY OF
THE DISEASES AT THE MOLECULAR LEVEL.
9. COUPLE OF QUESTIONS ON PSYCHIATRY MOSTLY DEPRESSION AND PERSONALITY
DISORDERS. BUT DO STUDY BEHAVIORAL SCIENCES IN DETAIL.
10. IMMUNOLOGY WAS ASKED IN GREATER DETAILS, INTERLEUKINS, LEUKOTRIENES AND
IMMUNODEFICENCIES.
11. QUESTIONS WERE LENGTHY BUT MOST OF THE TIMES THE THING WHICH WAS ASKED WAS
IRRELEVANT TO THE QUESTION. SO READ THE LAST LINE OF QUESTION FIRST TO APPROACH
IN THE RIGHT DIRECTION. MOST QUESTIONS IN CLINICAL VIGNETTE.
12. HEREDITARY MODES OF TRANSMISSION. (X-LINKED, AUTOSOMAL, LEARN THEM BY
PEDIGREE CHARTS)... VERY IMPORTANT.
13. MANY QUESTIONS ON GENETICS, VERY DIFFICULT, MOSTLY GENE STRUCTURE RELATED
(LAC OPERON), IF YOU WANNA DO GENETICS DO IT IN GREATER DETAILS.
14. READ THESE TOPICS IN DETAIL AND TRY TO LEARN THE MECHANISM AT MOLECULAR
LEVEL.
QUESTIONS ON CYSTIC FIBROSIS, ARTHRITIS, POST-STREP GN, GONORRHEA, SYPHILIS,
SKIN TEMP. REGULATION, THYROID, MYESTHENIA GRAVIS, CANCER CHEMOTHERAPY,
RHEUMATIC FEVER, SLE, BIOSTATISTICS, INFLAMMATORY CELL TYPES IN DIFFERENT BODY
REACTIONS (GENERAL PATHOLOGY), SUBSTANCE ABUSE, TOXICOLOGY, ALCOHOLISM,
DOCTOR-PATIENT RELATION, URINARY TRACT INFECTIONS, HEPATITIS, COPD,
H.O.C.MYOPATHY, LEUKEMIAS, CHOLESTEROL METABOLISM, GENERAL PHARMACOLOGY (DRUG
METABOLISM, DISTRIBUTION AND ELIMINATION).
15. THE EXAM WAS MOSTLY OF MOLECULAR /RECEPTOR LEVEL QUESTIONS. IT IS NO MORE AN
EXAM OF TRIGGER WORDS.
16. BEST THING WOULD BE TO DO ALL DISEASES/DRUGS/MICROBIAL MECHANISM AT
BIOCHEMICAL LEVEL.
17. AUTOIMMUNE DISEASES ARE VERY IMPORTANT. (RA, SLE)
EXPECTED TOPICS FOR OCTOBER STEP-1 EXAM:
DO ALL THE TOPICS OF JUNE 1998 EXAM PLUS THE MEDICAL ETHICS TOPICS, NORMAL CHILD
DEVELOPMENT, OLD AGE NORMAL CHANGES, PHARMACOLOGY CHARTS, SPECIFIC
MICRO-ORGANISMS (BACTERIA, VIRUS AND FUNGI) INVOLVED IN INFECTIONS AND THEIR
MECHANISMS AT MOLECULAR LEVEL, MECHANISM OF DRUGS IN DETAILS, MECHANISM OF
DISEASES IN DETAILS, IMMUNOLOGY, BIOCHEM. CYCLES WITH THE RATE LIMITING ENZYMES
INVOLVED, BIOSTATS, CARDIOVASCULAR (EVERY ASPECT), NEUROANATOMY AND IF YOU LEARN
THINGS WITH THE HELP OF BUZZ (TRIGGER) WORDS, THEN PLZ. DO KNOW THE MEANINGS OF
TRIGGER WORDS.
HELPFUL INTERNET SITES FOR STEP-1 MATERIALS:
1. KANSAS UNIVERSITY MED. CTR. (http://www.kumc.edu), GO TO BOARD REVIEW PAGE.
EXCELLENT SITE, DO VISIT THIS SITE.
2. UNIVERSITY OF UTAH, WEBPATH. (best site for pathology and hematology
diagrams).
3. UNIVERSITY OF IOWA, (best site for dermatology).
4. VERY GOOD SITE FOR DERMATOLOGY PICS. (http://www.derma.med.uni-erlangen.de).
5. FOR CT-SCANS (www.embbs.com). VERY GOOD SITE FOR X-RAYS, CT-SCANS, MRI.
6. UNIVERSITY OF PENNSYLVANIA, VERY GOOD SITE FOR USMLE.
GOOD LUCK TO ALL OF YOU. IF YOU HAVE ANY PROBLEM OR WOULD LIKE TO ADD ANY USEFUL
INFORMATION IN THIS DATA, PLZ. CONTACT ME ON MY E-MAIL (jkamal@hotmail.com).
Junaid Kamal
Jkamal@hotmail.com