Mistletoe. Genus Viscum

Medicinal and aromatic plants - Industrial profiles

Editor: A. Büssing

Harwood Academic Publishers, Amsterdam (2000)

280 pages, hardback, ISBN 90-5823-092-9, 116 Euro

With contributions of Donald W. Kirkup, Roger M. Polhill, Delbert Wiens, Hans Becker, Won-Bong Park, Teresa B. Fernández, Beatriz G.Varela, Carols A. Taira, Rafael A. Ricco, Alberto A. Gurni, Silvia E. Hajos , Elida M. C. Alvarez, Marcelo L. Wagner, Hartmut Ramm, Konrad Urech, Markus Scheibler, Gianfranco Grazi, Spiridon Kintzios, Maria Barberaki, Uwe Pfüller, Elmar Lorch, Wilfried Tröger, Gerburg M. Stein, Peter A. Berg, Josef Beuth, Michael Schietzel, and Arndt Büssing (ed.).

Viscum album is used as a remedy for at least 2,000 years, nowadays predominantly in complementary cancer therapy. Despite an obvious discrepancy between the popularity of mistletoe extracts and their classification as a non-conventional treatment modality with unproven efficacy in oncology, mistletoe is one of the most widely used adjuvant treatment of neoplastic disorders especially in the German speaking areas. This book contains a series of expert dissertations on mistletoes from Africa, Argentina, Europe and Korea, history, cultivation, development and processing, description of relevant compounds, pharmacology and toxicology, and current market trends, i.e. development of a recombinant toxic lectin from Viscum album.

The book provides a comprehensive overview of current knowledge in mistletoe use from well recognised researches from Argentina, England, Greece, Korea, Switzerland, USA and Germany, and will be an invaluable reference source for anyone with an interest in the wide range of applications of this plant and its therapeutic potential in cancer therapy.

Which well known plant never touches the ground, does not follow a 12-month vegetation cycle, stays green year round, blooms in the winter, and sells predominately in December? The answer, of course, is mistletoe. Current research questions the efficacy of this highly controversial plant. "Rejected by clinical oncologists but used by practitioners and cancer patients, it is applied as a remedy to treat a broad spectrum of different diseases, such as epilepsy, diabetes, hypertension, arthrosis, hepatitis, HIV infection, labour pains, and cancer."

Now a new book on the therapeutic uses and industrial applications of Viscum has been published. Rarely mentioned in traditional books on herbal medicine mistletoe research remains questionable. Because the "extracts may exert different effects than purified substances" individual immune responses vary greatly. There is a great need for further investigation. Currently no clinical data are available documenting long-term therapy treatment.

Whether the extracts of Viscum become a major player in the fight against cancer, this book makes for provocative reading. Researchers in pharmacognosy and phystochemistry will find this book documented with references to hundreds of research articles invaluable. While most articles feature the European point of view, there is one article from Japan and another from South Africa. Although none of the articles originate from the United States, American research is well represented in the bibliographies, as are traditional Chinese uses for this herb.

Responding to the increased demand for information on medicinal and aromatic plants this fascinating look at this highly controversial plant is the 16th volume in the series Medicinal and Aromatic Plants Industrial Profiles. This series brings together articles scattered through a variety of sources, is international in scope, and includes many little known sources. Each article is well documented and is introduced by the editor Arndt Bussing, head of the Department of Applied Immunology at the foundation Krebsforschung Herdecke, University of Witten/Herdecke. Mistletoe: the Genus Viscum is illustrated with color photographs of the plant, line drawings, and chemical structures. With few exceptions most references are current, dating from 1990 to 2000.

While this book would be of interest to scientists in botany, agriculture, and phytochemistry, those working in alternative medicine, pharmaceutical, and health sciences should find it of greater interest. Recommended for academic and research libraries.
Reviewer: Arlieda Ries, Physical Sciences Librarian, Miami University Brill Science Library, riesa@muohio.edu

Contents

 

  • Introduction: The magic potion - History of mistletoe uses. By Arndt Büssing
  • Viscum in the context of its familiy, Viscaceae, and its diversity in Africa. By Donald W. Kirkup, Roger M. Polhill and Delbert Wiens
  • European mistletoe: Taxonomy, host trees, parts used, physiology. By Hans Becker
  • Korean mistletoes and other East-Asian populations. By Won-Bong Park
  • Mistletoes from Argentina. Ligaria cuneifolia var. cuneifolia as a substitute for the European mistletoe (Viscum album). By Teresa B. Fernández, Beatriz G.Varela, Carols A. Taira, Rafael A. Ricco, Alberto A. Gurni, Silvia E. Hajos , Elida M. C. Alvarez, and Marcelo L. Wagner
  • Cultivation and development of Viscum album L. By Hartmut Ramm, Konrad Urech, Markus Scheibler and Gianfranco Grazi
  • The biotechnology of Viscum album L.: tissue culture, somatic embryogenesis and protoplast isolation. By Spiridon Kintzios and Maria Barberaki
  • Chemical constituents of European mistletoe (Viscum album L.). By Uwe Pfüller
  • Biological and pharmacological properties of Viscum album L.- From tissue flask to man. By Arndt Büssing
  • Viscum album products. By Arndt Büssing
  • Pharmaceutical quality control of mistletoe preparations. By Elmar Lorch and Wilfried Tröger
  • Toxicology of mistletoe extracts and their components. By Gerburg M. Stein
  • Adverse effects during therapy with mistletoe extracts. By Gerburg M. Stein and Peter A. Berg
  • Natural versus recombinant mistletoe lectin. Market trends. By Josef Beuth
  • The magic potion becomes serious: whole plant extracts vs. defined components. By Gerburg M. Stein and Michael Schietzel