Buffalo Bills 1997-98 Season Schedule
Home games are in CAPS!
All times listed are Eastern.
| Date | Opponent | Time |
| August 31 | MINNESOTA | 8:00 PM |
| September 7 | at New York Jets | 1:00 PM |
| September 14 | at Kansas City | 1:00 PM |
| September 21 | INDIANAPOLIS | 4:00 PM |
| September 28 | Bye Week | |
| October 5 | DETROIT | 1:00 PM |
| October 12 | at New England | 1:00 PM |
| October 20 | at Indianapolis | 9:00 PM (Monday) |
| October 26 | DENVER | 1:00 PM |
| November 2 | MIAMI | 1:00 PM |
| November 9 | NEW ENGLAND | 4:00 PM |
| November 17 | at Miami | 9:00 PM (Monday) |
| November 23 | at Houston | 1:00 PM |
| November 30 | NEW YORK JETS | 1:00 PM |
| December 7 | at Chicago | 1:00 PM |
| December 14 | JACKSONVILLE | 1:00 PM |
| December 20 | at Green Bay | 12:20 PM (Saturday) |