Nathalie SCHNETZ-BOUTAUD, Ph.D.

4505 Idaho avenue

Nashville, Tennessee 37209 U.S.A.

(615) 298-2756

PROFESSIONAL ADDRESS

Vanderbilt University

Department of Chemistry

SC-5112, Box 1822, Station B

Nashville, Tennessee 37235 U.S.A.

Phone : (615) 322-6074 Fax : (615) 343-0384

EMAIL schnetz@toxicology.mc.vanderbilt.edu

Training


1990 : D.E.A. in Medicinal Chemistry (equivalent to Advanced Graduate Degree in Pharmacology). (Louis Pasteur University, Strasbourg, France)

1994 : Ph.D. in Medicinal Chemistry. (Louis Pasteur University, Strasbourg, France)


1994-98: Research associate in the laboratory of Pr. L.J. Marnett - Biochemistry Department - Vanderbilt University - Nashville - TN 37232-0146

Tel: (615) 343 7329

1998-present : Research associate in the laboratory of Pr. M. P. Stone - Chemistry Department - Vanderbilt University - Nashville - TN 37235

Tel: (615) 322 2589

Publications:

T. Desai, A. Fernandes-Mayoralas, J. Gigg, R. Gigg, C. Jarmillo, S. Payne, S. Penades, and N. Schnetz : Preparation of Optically Active myo-inositol Derivatives as Intermediates for the Synthesis of Inositol Phosphates in Inositol-Phosphates and derivatives ; Synthesis Biochemistry and Therapeutic Potential. (Edited by A.B.Reitz American Chemical Society) 1991 Chapitre 6 pages 86-102.

N. Schnetz-Boutaud , B. Spiess and G. Schlewer: Synthesis of (±) 3,6-di-O-benzyl-2-myo-inosose 1,4,5-tri-O-dibenzylphosphate as potential intermediate for the preparation of tritium-labelled myo-inositol 1,4,5-trisphosphate. Carbohydrate Research, 259, (1994), 135-140.

T. Desai, J. Gigg, R. Gigg, E. Martin-Zamora, N. Schnetz : The synthesis and resolution of (±)-1,4-di-O-benzyl-2,3-O-isopropylidene-myo-inositol. Carbohydrate Research, 258, (1994), 135-144.

N. Schnetz , P. Guedat, B. Spiess, G. Schlewer: Synthesis of thio analogues of myo-inositol-1 monophosphate, as possible inhibitors of myo-inositol-1 monophosphatase. Bull. Soc. Chim. Fr.,133, (1996) 205-208.

L.J. Niedernhofer, M. Riley, N. Schnetz-Boutaud , G. Sanduwaran, A. Chaudhary, G. R. Reddy, and L. J. Marnett: Temperature-dependent formation of a conjugate between Tris buffer and the malondialdehyde DNA adduct, pyrimidopurinone. Chem. Res. Tox., 10, (1997), 556-561.

M. F. Hashim, N. Schnetz-Boutaud , L. J. Marnett: Replication of Template -Primers Containing propanodeoxyguanosine by DNA polymerase b. J. Bioch. Chem., 272, (1997), 20205-12.

H. J. Einolf, N. Schnetz-Boutaud and F. P. Guengerich: Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases. Biochemistry, 37, (1998), 130300-12.

H. Mao, N. Schnetz-Boutaud , J. P. Weisenseel, L. J. Marnett and M.P. Stone: Duplex catalyses the chemical rearrangement of a malondialdehyde deoxyguanosine adduct. Proc. Natl. Acad. Sci. USA, 96 (1999) 6615-6620.

Communication at meetings:

Synthesis of [3H2] myo-inositol 1,4,5-trisphosphate. Semaine d'Etudes en Chimie Organique (SECO 29) ; May 1992. N. Schnetz and G. Schlewer.

Synthesis of [3H2] myo-inositol 1,4,5-trisphosphate. REGIONEUREX ; Freiburg in Brisgau ; October 1992. N. Schnetz and G. Schlewer.

Synthesis de [3H2] myo-inositol 1,4,5-trisphosphate. Join metting ULP, Marion Merrel Dow. N. Schnetz and G. Schlewer

Synthesis of M1GTP and its enzymatic incorporation into DNA. 212th ACS National Meeting, Orlando, Aout 1996. N. Schnetz-Boutaud and L.J. Marnett

Incorporation of 8-oxo-7,8-dihydroguanine triphosphate into DNA by T7 polymerase exo- and HIV-1 reverse transcriptase. H. J. Einolf, N. Schnetz-Boutaud and F. P. Guengerich.

Reactivity of Primary amines with the malondialdehyde-DNA adduct, 1,N2-pyrimidopurinone. N. Schnetz-Boutaud , P. F. Scholl, M. F. Hashim and L. J. Marnett. AACR, 89 annual meeting, New Orleans, March 1998.

Replication of template-primer containing M1G. AACR, 89 annual meeting, New Orleans, March 1998.

Kinetics of 8-oxo-7,8-dihydrodeoxyguanosine triphosphate incorporation into DNA by replicative and repair DNA polymerases. Einolf, H.J., Schnetz-Boutaud, N. , and Guengerich, F.P. AACR, 89 annual meeting, New Orleans, March 1998.

Nombre de visiteurs depuis le 22/12/99