Poser Criteria
Diagnosing Multiple Sclerosis
An
exacerbation
is defined as:
the appearance of a new clinical
Sign
/Symptom
or the clinical worsening of a previous Sign/
Symptoms
that had been stable for at least the previous 30 days
and which persisted for a minimum of 24 hours.
Source:
Poser, CM; Paty, DW; Scheinber, L; et al.
Ann Neurol 1983; 13(3); 227-231
"New Diagnostic Criteria For Multiple Sclerosis; Guidelines For Research Protocols"
Diagnostic Categories for Multiple Sclerosis
Definite MS:
Consistent course (
Relapsing/Remitting
) with at least 2 bouts, separated by at least 1 month; or slow, stepwise
Progressive
course for at least 6 months
Documented Neurologic
Signs
of
Lesions
in more than one area (
Functional System
) of Brain or Spinal Cord
White Matter
Onset of
Symptoms
between 10 and 50 years of age
Absence of other more likely Neurologic explanation
Probable MS:
History of Relapsing/Remitting
Symptoms
Signs
not documented and only one current Sign, commonly associated with MS
Documented single bout of Symptoms with Signs, of more than one White Matter Lesion
Good recovery, then variable Symptoms and
Signs
Absence of other more likely Neurologic explanation
Possible MS:
History of Relapsing/Remitting
Symptoms
No documentation of Signs establishing more than one White Matter Lesion
Absence of other more likely Neurologic explanation
Source
MRI & Poser Criteria
David H. Miller MB, ChB, MD, FRACP
Institute of Neurology, MS NMR Research Unit, London, UK
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