National Library of Medicine: IGM Full Record Screen 


 TITLE: 
                  Blood dehydroepiandrosterone sulphate (DHEAS) levels
                  in pemphigoid/pemphigus and psoriasis.
 AUTHOR: 
                  de la Torre B; Fransson J; Scheynius A
 AUTHOR
 AFFILIATION: 
                  Department of Clinical Neuroscience, Karolinska
                  Hospital, Stockholm, Sweden.
 SOURCE: 
                  Clin Exp Rheumatol 1995 May-Jun;13(3):345-8
 NLM CIT. ID: 
                  96044538
 ABSTRACT: 
                  Serum dehydroepiandrosterone sulphate (DHEAS) levels
                  and diagnostic autoantibody titers were measured in
                  patients with pemphigoid/pemphigus [n = 46/4; 21 men
                  and 29 women, 42 to 93 years of age (mean 79)].
                  Twenty-four patients were either on peroral
                  Prednisolone (n = 11), or topical treatment with
                  betamethasone (n = 13), and the other 26 were either
                  receiving non-steroidal drugs or were untreated. Their
                  DHEAS levels were compared to those of 20 patients
                  with psoriasis, and to 23 patients with secondary
                  osteoarthritis (OA). Assessing the patients by group,
                  the mean DHEAS level was markedly lower in the
                  pemphigoid/pemphigus than in the psoriasis and OA
                  patients (geometric mean 600 vs. 2130 and 2100 nmol/l,
                  respectively; p < 0.001). This difference was
                  independent of steroid treatment. No correlation was
                  found between the DHEAS levels and antibody titers.
                  The low levels found in pemphigoid/pemphigus are
                  concordant with those reported for systemic lupus
                  erythematosus, rheumatoid arthritis and polymyalgia
                  rheumatica/giant cell arteritis. DHEAS deficiency is a
                  permanent feature in these autoimmune diseases, and
                  may contribute to their etiology and/or
                  pathophysiology.
 MAIN MESH
 SUBJECTS: 
                  Pemphigoid, Bullous/*BLOOD/DIAGNOSIS/DRUG THERAPY
                  Pemphigus/*BLOOD/DIAGNOSIS/DRUG THERAPY
                  Prasterone/*ANALOGS & DERIVATIVES/BLOOD
                  Psoriasis/*BLOOD/DIAGNOSIS/DRUG THERAPY 
 ADDITIONAL
 MESH SUBJECTS:
                  Adult
                  Aged
                  Aged, 80 and over
                  Anti-Inflammatory Agents, Non-Steroidal/THERAPEUTIC
                  USE
                  Anti-Inflammatory Agents, Steroidal/THERAPEUTIC USE
                  Autoantibodies/BLOOD
                  Betamethasone/THERAPEUTIC USE
                  Comparative Study
                  Female
                  Human
                  Male
                  Middle Age
                  Osteoarthritis/BLOOD
                  Prednisolone/THERAPEUTIC USE 
 PUBLICATION
 TYPES: 
                  JOURNAL ARTICLE 
 LANGUAGE: 
                  Eng
 REGISTRY
 NUMBERS: 
                  0 (Anti-Inflammatory Agents, Non-Steroidal)
                  0 (Anti-Inflammatory Agents, Steroidal)
                  0 (Autoantibodies)
                  378-44-9 (Betamethasone)
                  50-24-8 (Prednisolone)
                  53-43-0 (Prasterone)
                  651-48-9 (Dehydroepiandrosterone Sulfate)