The Effects of Terbutaline on Children


Does Use of This Preterm Labor Drug Have Long-Term Consequences?

This is a forum for concerned parents. Because I have received so many e-mails from concerned parents, I have created a message board (see, below) where they can post messages and network with each other.

Meanwhile, here are summaries of two studies I have found on this topic. I have found very little information on terbutaline's effects on children exposed in utero.

This first study examined 66 surviving infants whose mothers had been treated with isoxsuprine, ritodrine and terbutaline (they're all in the same family of drugs). The infants were examined at 10 and 18 months. Two of the infants had psychomotor disturbances and 2 had severe hemiparesis (weakness or paralysis). "It was felt that these infants had a better start in life being more mature at birth." (Karlsson, K., et al., "Comparison of Various Beta-Mimetics on Preterm Labor, Survival and Development of the Child," Journal of Perinatology, 1980, Vol. 8, pp. 19).

The second study involved 54 infants whose moms had taken terbutaline. They were followed for their first two years, with exams at 10 and 14 months. Three (5.5%) were found to have an abnormal neurodevelopmental status at 2 years of age. (Svenningsen, NW, "Followup studies on Preterm Infants After maternal Beta-Receptor Agonist Treatment," Acta Obstetrics and Gynecology Scandinavia, 1982, (Supp. 108), pp. 67-70).

Disclaimer: I am not a physician and this should not serve as any form of medical advice.